July 1959 marks the first month where Krypto is completely taken for granted as a member of Superboy's supporting cast, as much as Pa and Ma Kent, Lana, or perhaps closer to Pete Ross. In two Super-titles this month, Krypto appears, but is not central to either story.
In Superboy #74's "Superboy’s Voyage to New Krypton", Jor-El and Lara show up in Smallville and Superboy uproots his adoptive family AND Krypto to New Krypton, a planet with properties similar to the long-dead world. It's not great for Ma and Pa who now weigh a ton, nor does Krypto appreciate being turned into an ordinary pooch.
In Superman #130's "The Curse of Kryptonite!", Superman is downed by a kryptonite boulder and tries to think his way out of the predicament - essentially turning the strip into a clip show of many other times he's been struck by Green K sickness - and then Krypto shows up as a Doggie ex Machina.