A few bits starring the super-pup this week... Starting with Superman #160, in which the Man of Steel is dosed with Gold Kryptonite dust and loses his powers, nevertheless races to the Arctic and parachutes near the Fortress of Solitude to find a cure, and almost from hypothermia, until Krypto comes across him. Does Clark's faithful sled dog get him to civilization in time?
In the same issue, Superman becomes a "Policeman of Steel" for a day, which of course means Krypto is roped into the K-9 unit. Of course, it's mostly about making giant commemorative badges.
Tracking back to Superman #159, an imaginary story where Lois Lane is sent to Krypton and become the Maid of Steel, that world's Krypto is, of course, a normal dog. Still an astronaut though!