This is Howard Koss-El, and today we witness a clash of titans, a battle between Boy and Dog, a conflict for the ages. Superboy v Krypto. And you won't believe how far these Kryptonian giants are willing to go to hurt one another. But why would they fight, you ask? It's all because of the Superboy Revenge Squad who think they have Red Kryptonite radiation figured out. Sample #3, to wit, is supposed to fill them with Super-Hate!
He survives! ROUND THREE: Monkey business!
Meanwhile, in Superman #174... an android Superman creates a robot Krypto in a bid to make Clark Kent think he's got crazy